FAQs

How Does It Work?

HOW LONG DOES ANNOVERA LAST?

ANNOVERA is a long-term birth control that lasts up to one year (13 cycles).* With your prescription, its just one trip to the pharmacy for one year of birth control in one ring.

*For each cycle, ANNOVERA is inserted and left in place for 21 continuous days and then removed for 7 days.

IS ANNOVERA EFFECTIVE AT PREVENTING PREGNANCY?

Yes. ANNOVERA delivers long-term (13 cycles)* contraception that’s just as effective as the daily pill.

*For each cycle, ANNOVERA is inserted and left in place for 21 continuous days and then removed for 7 days

IS ANNOVERA FDA-APPROVED?

Yes!

DOES ANNOVERA PROTECT AGAINST HIV OR STDS?

No. Condoms are still your best bet to prevent against HIV or STDs. ANNOVERA is compatible with male condoms made with natural rubber latex, polyisoprene, and polyurethane.

HOW SHOULD I USE ANNOVERA?

You can insert and remove it yourself, giving you more control over your fertility and periods.

See How Do I Use It? page for additional detail.

WHAT DOES ANNOVERA FEEL LIKE?

It’s a soft and squishy ring that fits comfortably in your body. Most women don’t feel ANNOVERA once it is in place.

CAN YOU USE ANNOVERA DURING SEX?

Yes, it is designed to be worn during sex. If you prefer, you can remove it for up to 2 hours. If ANNOVERA is out of your vagina for more than 2 hours at one time or at different times that add up to more than 2 hours over the first 21 days of your cycle, then you will need to use another method of birth control (such as male condoms or spermicide) until ANNOVERA has been in your vagina for 7 consecutive days.

HOW IS IT DIFFERENT FROM OTHER VAGINAL RINGS?

Unlike other vaginal rings that are monthly and only last one cycle, ANNOVERA is a soft, flexible ring that is annual, lasting a full 13 cycles.*

*For each cycle, ANNOVERA is inserted and left in place for 21 continuous days and then removed for 7 days.

WHAT DO OTHER WOMEN HAVE TO SAY ABOUT ANNOVERA?

Overall, nearly 90% of women in a clinical trial were satisfied with ANNOVERA as a form of contraception. Patients rated ANNOVERA on product characteristics related to ease-of use (simple insertion, simple removal, simple cleaning), comfort (soft and flexible, not felt while wearing), expulsion (not expelled while wearing or during sex), and physical effects during sexual activity (no change in sexual pleasure or frequency).

DO I NEED TO SEE MY HEALTHCARE PROVIDER TO STOP USING ANNOVERA?

No! ANNOVERA does not require a healthcare visit for insertion or removal. You can easily remove ANNOVERA on your own if you change your mind about taking birth control.

What's Inside?

DOES ANNOVERA HAVE HORMONES?

Yes. ANNOVERA is a combination hormonal contraceptive. It releases one of the lowest daily doses of ethinyl estradiol on the market (0.013 mg/day) and includes a new kind of progestin (0.15 mg/day). It continuously releases a low stream of these two hormones into your vagina, which then enter your blood.

DO THE HORMONES IN ANNOVERA WORK THE SAME AS THE PILL?

Yes. ANNOVERA is a combination hormonal contraceptive that contains a form of estrogen (ethinyl estradiol) to prevent ovulation and a progestin (segesterone acetate) that works by changing the cervical mucus and the lining of the uterus (endometrium) to keep sperm from joining the egg.

WHAT IS ANNOVERA MADE OF?

ANNOVERA is made of silicone and is latex-free. It contains two female hormones, an estrogen (ethinyl estradiol) and a progestin (segesterone acetate).

The inactive ingredients in ANNOVERA are dibutyltin dilaurate, silicone elastomers, silicone medical adhesive, and titanium dioxide. The elastomers are all methyl siloxan-based polymers.

How Do I Care For It?

HOW DO I KEEP IT CLEAN?

Keeping ANNOVERA clean between uses is easy. ANNOVERA should be washed with mild soap and water and rinsed and patted dry with a clean cloth towel or paper towel prior to each insertion and at each removal.

WHERE DO I STORE ANNOVERA WHEN I TAKE IT OUT?

It comes with a small case for convenient and discreet storage. It looks like a makeup compact case!

DOES IT REQUIRE REFRIGERATION?

No.

CAN ANNOVERA GET LOST INSIDE ME?

No. There’s nowhere for it to go – it will stay in your vagina.

WHAT SHOULD I DO IF ANNOVERA COMES OUT OF MY VAGINA?

ANNOVERA can be accidently expelled. Accidental expulsion could occur while removing a tampon, during sex, or with straining during a bowel movement. You have up to 2 hours to put it back in and as long as it hasn’t been out for more than 2 hours in the first 21 days of the cycle, contraceptive efficacy isn’t reduced and you don’t need to use backup contraception. Wash ANNOVERA with mild soap and water before re-inserting the ring.

CAN I STILL USE TAMPONS?

Yes. ANNOVERA is to be used for a continuous period of 21 days (3 weeks), and removed for 7 days.

You can use tampons during the 7 days ANNOVERA is not inside your vagina.

SIDE EFFECTS?

WHAT ARE THE MOST COMMON SIDE EFFECTS THAT CAUSE WOMEN TO STOP USING ANNOVERA?

In the clinical trials, the most common side effects that caused women to stop using ANNOVERA were abnormal bleeding (1.7%), headache/migraine (1.3%), vaginal discharge/infections (1.3%), and nausea/vomiting (1.2%).

WHAT ARE THE MOST COMMON SIDE EFFECTS OF ANNOVERA?

The most common side effects reported by women taking ANNOVERA in a study were headache/migraine, nausea/vomiting, fungal infections, abdominal pain lower/upper, menstrual cramps, vaginal discharge, urinary tract infection, breast tenderness/pain/discomfort, bleeding irregularities including intermenstrual bleeding, diarrhea, and genital itching.

WHO SHOULD NOT USE ANNOVERA?

DO NOT USE ANNOVERA IF YOU:

  • smoke and are over 35 years old.
  • have or have had a blood clot in your arms, legs, lungs, or eyes.
  • have had a stroke.
  • have reduced blood flow to your brain (cerebrovascular disease).
  • have reduced blood flow or blockage in 1 or more of the arteries that supply blood to your heart (coronary artery disease).
  • have had a heart attack.
  • have heart rhythm or heart valve problems that increase your risk of having blood clots, such as an infection of the inner lining of the heart and heart valves or a type of irregular heartbeat called atrial fibrillation.
  • have heart rhythm or heart valve problems that increase your risk of having blood clots, such as an infection of the inner lining of the heart and heart valves or a type of irregular heartbeat called atrial fibrillation.
  • have a problem with your blood that makes it clot more than normal.
  • have high blood pressure that is not controlled with medicine or have high blood pressure with blood vessel damage.
  • have diabetes and are over 35 years old; have diabetes with high blood pressure or problems with your kidneys, blood vessels, eyes, or nerves; or have had diabetes for longer than 20 years.
  • have headaches with changes in vision, numbness or weakness, have migraine headaches with aura, or are over age 35 years old and have any type of migraine headaches.
  • have liver disease or liver tumors.
  • have or have had breast cancer or any cancer that is sensitive to the female hormones estrogen or progesterone.
  • have or have had breast cancer or any cancer that is sensitive to the female hormones estrogen or progesterone.
  • have unexplained vaginal bleeding.
  • are allergic to segesterone acetate, ethinyl estradiol, or any of the ingredients in ANNOVERA.
  • take any Hepatitis C drug combination medicine containing ombitasvir/paritaprevir/ritonavir, with or without dasabuvir. This may increase levels of the liver enzyme alanine aminotransferase (ALT) in the blood.

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Important Risk Information


  • Do not use ANNOVERA if you smoke cigarettes and are over 35 years old. Smoking increases your risk of serious heart and blood vessel (cardiovascular) side effects from hormonal birth control methods, including death from heart attack, blood clots, or stroke. This risk increases with age and the number of cigarettes you smoke.
  • ANNOVERA does not protect against HIV infection (AIDS) and other sexually transmitted infections.
  • The use of a combination hormonal contraceptive (CHC), like ANNOVERA, is associated with increased risks of several serious side effects, including blood clots, stroke, or heart attack. Do not use ANNOVERA if you have a history of these conditions or any condition that makes your blood more likely to clot. The risk of blood clots is highest when you first start using CHCs and when you restart the same or different CHC after not using it for 4 weeks or more.
  • ANNOVERA is also not for women with high blood pressure that medicine can’t control or high blood pressure with blood vessel damage; diabetes and over 35 years old, diabetes with high blood pressure or kidney, eye, nerve, or blood vessel damage, diabetes for longer than 20 years; certain kinds of severe migraine headaches; liver disease or liver tumors; breast cancer or any cancer that is sensitive to the female hormones estrogen or progesterone; unexplained vaginal bleeding; are allergic to segesterone acetate, ethinyl estradiol or any other ingredients in ANNOVERA; or take any Hepatitis C drug combination containing ombitasvir/ paritaprevir/ritonavir, with or without dasabuvir, as this may increase levels of the liver enzyme “alanine aminotransferase” (ALT) in the blood.
  • ANNOVERA can cause serious side effects, including: blood clots; toxic shock syndrome (TSS); liver problems, including liver tumors; high blood pressure; gallbladder problems; changes in the sugar and fat (cholesterol and triglycerides) levels in your blood; headache; irregular or unusual vaginal bleeding and spotting between your menstrual periods; depression; possible cancer in your cervix; swelling of your skin especially around your mouth, eyes, and in your throat (angioedema); dark patches of skin on your forehead, cheeks, upper lip, and chin (chloasma). Call your healthcare provider or get emergency medical care right away if any of the serious side effects occur.
  • The most common side effects reported in at least 5% of women who received ANNOVERA were: headache/migraine, nausea/vomiting, vaginal yeast infection (candidiasis), lower/ upper abdominal pain, painful periods, vaginal discharge, urinary tract infection, breast pain/tenderness, irregular vaginal bleeding, diarrhea, and genital itching.


Use


ANNOVERA is a ring-shaped vaginal system with hormones used by females to prevent pregnancy. ANNOVERA has not been adequately studied in moderately obese females. Ask your doctor if ANNOVERA is appropriate for you.




The risk information provided here is not complete. To learn more, review the ANNOVERA Patient Information and talk with your healthcare provider or pharmacist. The FDA-approved product labeling, including Patient Information, can be found here.


You may report side effects to the FDA at www.fda.gov/medwatch or by calling 1-800-FDA-1088. You may also report side effects to TherapeuticsMD, Inc. at 1-888-228-0150.

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